| Strikeouts | |||
| Players | Teams | SO | IP |
| Smoltz,J | JIM | 226 | 231.1 |
| Brown,K | KEN | 218 | 293.2 |
| Leiter,A | JOE | 205 | 242.0 |
| Clemens,R | SPS | 200 | 196.0 |
| Guzman,J | KEN | 189 | 275.0 |
| Fassero,J | GREG | 185 | 214.1 |
| Pettitte,A | GREG | 185 | 247.2 |
| Sanders,S | PETE | 168 | 167.1 |
| Schilling,C | KEN | 168 | 193.1 |
| Hentgen,P | JOHN | 167 | 248.0 |