| Strikeouts | |||
| Players | Teams | SO | IP |
| Johnson, R | DOGS | 281 | 268.2 |
| Mussina, M | TURK | 224 | 256.1 |
| Zito, B | GNAT | 217 | 252.0 |
| Schilling, C | TURK | 216 | 251.2 |
| Vazquez, J | RAIN | 188 | 231.2 |
| Wood, K | GNAT | 186 | 166.1 |
| Sabathia, C | BLIT | 183 | 181.0 |
| Clemens, R | GARD | 178 | 195.2 |
| Washburn, J | TRUF | 176 | 236.1 |
| Morris, M | GARD | 175 | 256.1 |