| Strikeouts | |||
| Players | Teams | SO | IP |
| Martinez, P | GN | 326 | 293.0 |
| Johnson, R | BT | 254 | 260.2 |
| Millwood, K | JH | 235 | 271.2 |
| Smoltz, J | KHK | 220 | 232.1 |
| Hampton, M | DB | 193 | 269.0 |
| Brown, K | KRK | 191 | 245.1 |
| Mussina, M | SS | 190 | 239.2 |
| Cone, D | CK | 169 | 213.1 |
| Moyer, J | KHK | 151 | 228.0 |
| Lima, J | GH | 145 | 215.2 |