| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 4/6/2009 | MAN | Theriot | Promoted to active roster | | | Before |
| 4/10/2009 | MIA | Baek | Signed | | | Before |
| 4/10/2009 | MIA | Baek | Demoted to reserve roster | | | Before |
| 4/10/2009 | MIA | De La Rosa | Signed | | | Before |
| 4/10/2009 | MIA | De La Rosa | Demoted to reserve roster | | | Before |
| 4/10/2009 | MIA | Francisco,B | Signed | | | Before |
| 4/10/2009 | MIA | Francisco,B | Demoted to reserve roster | | | Before |
| 4/10/2009 | MIA | Moss | Signed | | | Before |
| 4/10/2009 | MIA | Moss | Demoted to reserve roster | | | Before |
| 4/10/2009 | MIA | Snell | Signed | | | Before |
| 4/10/2009 | MIA | Snell | Demoted to reserve roster | | | Before |
| 4/11/2009 | MAN | Santiago | Promoted to active roster | | | Before |
| 4/19/2009 | MIS | Parra | Promoted to active roster | | | Before |
| 4/20/2009 | IND | Washburn | Promoted to active roster | | | Before |
| 4/20/2009 | IND | Wilson,Br | Promoted to active roster | | | Before |
| 4/20/2009 | MEM | Kent | Promoted to active roster | | | Before |
| 4/20/2009 | MEM | Scutaro | Promoted to active roster | | | Before |
| 4/25/2009 | FAR | Glavine | Promoted to active roster | | | Before |
| 4/25/2009 | FAR | Wolf | Demoted to reserve roster | | | Before |
| 4/25/2009 | IND | Harris,B | Promoted to active roster | | | Before |
| 4/25/2009 | MAN | Maddux | Promoted to active roster | | | Before |
| 4/29/2009 | BUF | Cunningham | Promoted to active roster | | | Before |
| 4/30/2009 | MAN | Santiago | Demoted to reserve roster | | | Before |
| 4/30/2009 | MAN | Santiago | Promoted to active roster | | | Before |
| 5/1/2009 | SJ | Taveras,W | Promoted to active roster | | | Before |
| 5/1/2009 | SJ | Valbuena | Promoted to active roster | | | Before |
| 5/2/2009 | BUF | Cunningham | Demoted to reserve roster | | | Before |
| 5/2/2009 | BUF | Rodriguez,S | Promoted to active roster | | | Before |
| 5/2/2009 | MAN | Santiago | Demoted to reserve roster | | | Before |
| 5/12/2009 | MAN | Maddux | Demoted to reserve roster | | | Before |
| 5/22/2009 | BUF | Teagarden | Demoted to reserve roster | | | Before |
| 5/24/2009 | IND | Zito | Demoted to reserve roster | | | Before |
| 5/26/2009 | HAR | Denker | Released | | | Before |
| 5/26/2009 | HAR | Pearce | Demoted to reserve roster | | | Before |
| 5/26/2009 | HAR | Sanchez,F | Signed | | | Before |